Autophagy Deficiency Promotes -Lactam Production in Penicillium chrysogenum †
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چکیده
Autophagy Deficiency Promotes -Lactam Production in Penicillium chrysogenum † Magdalena Bartoszewska, Jan A. K. W. Kiel, Roel A. L. Bovenberg, Marten Veenhuis, and Ida J. van der Klei* Molecular Cell Biology, and Kluyver Centre for Genomics of Industrial Fermentation, University of Groningen, P.O. Box 14, 9750 AA Haren, Netherlands, and DSM Biotechnology Center, P.O. Box 425, 2600 AK, Delft, Netherlands
منابع مشابه
Uptake of the -Lactam Precursor -Aminoadipic Acid in Penicillium chrysogenum Is Mediated by the Acidic and the General Amino Acid Permease
External addition of the -lactam precursor -aminoadipic acid to the filamentous fungus Penicillium chrysogenum leads to an increased intracellular -aminoadipic acid concentration and an increase in penicillin production. The exact route for -aminoadipic acid uptake is not known, although the general amino acid and acidic amino acid permeases have been implicated in this process. Their correspon...
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UNLABELLED Secondary metabolism in Penicillium chrysogenum was intensively subjected to classical strain improvement (CSI), the resulting industrial strains producing high levels of β-lactams. During this process, the production of yellow pigments, including sorbicillinoids, was eliminated as part of a strategy to enable the rapid purification of β-lactams. Here we report the identification of ...
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This study aimed at developing an alternative host for the production of penicillin (PEN). As yet, the industrial production of this beta-lactam antibiotic is confined to the filamentous fungus Penicillium chrysogenum. As such, the yeast Hansenula polymorpha, a recognized producer of pharmaceuticals, represents an attractive alternative. Introduction of the P. chrysogenum gene encoding the non-...
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